Article
Thyrotropin receptor antibodies and a genetic hint in antithyroid drug-induced adverse drug reactions.
Expert opinion on drug safety - 1 Aug 2018
Chang Lin-Chau, Chang Chien-Ching, Chen Pei-Lung, Wang Shun-Huo, Chen Yi-Hsuan, Tsai Yung-Hsin, Shih Shyang-Rong, Chiu Wei-Yih, Fann Cathy Shen-Jang, Yang Wei-Shiung, Chang Tien-Chun
Abstract excerpt
BACKGROUND: Antithyroid drugs (ATDs) are known to cause various adverse drug reactions (ADRs) that can lead to treatment complexity and unpredictable risks. With the aim of ensuring safer drug use, we assessed whether thyrotropin receptor antibody (TRAb) titers are associated with ATD-induced cutaneous reactions and/or hepatotoxicity, and examined potential genetic predisposition factors. METHODS: We compared...
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