Article
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
PloS one - 1 Jan 2015
Scheiner Bernhard, Mandorfer Mattias, Schwabl Philipp, Payer Berit Anna, Bucsics Theresa, Bota Simona, Aichelburg Maximilian C, Grabmeier-Pfistershammer Katharina, Stättermayer Albert, Ferenci Peter, Trauner Michael, Peck-Radosavljevic Markus, Reiberger Thomas
Abstract excerpt
BACKGROUND: Faster fibrosis progression and hepatic steatosis are hallmarks of HIV/HCV coinfection. A single nucleotide polymorphism (SNP) of the PNPLA3-gene is associated with development of non-alcoholic steatohepatitis and a worse outcome in alcoholic liver disease. However, the role of PNPLA3 rs738409 SNP on liver fibrosis and steatosis, portal hypertension, and virological response in HIV/HCV coinfection...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.