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Article

Genetic polymorphisms associated with fatty liver disease and fibrosis in HIV positive patients receiving combined antiretroviral therapy (cART).

PloS one - 1 Jan 2017

Dold Leona, Luda Carolin, Schwarze-Zander Carolynne, Boesecke Christoph, Hansel Cordula, Nischalke Hans-Dieter, Lutz Philipp, Mohr Raphael, Wasmuth Jan-Christian, Strassburg Christian P, Trebicka Jonel, Rockstroh Jürgen Kurt, Spengler Ulrich

Abstract excerpt

Hepatic steatosis can occur with any antiretroviral therapy (cART). Although single nucleotide polymorphisms (SNPs) have been identified to predispose to alcoholic and non-alcoholic fatty liver disease, their role for treatment-associated steatosis in HIV-positive patients remains unclear. We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF...

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Share to Acyltransferases
Share to Anti-Retroviral Agents
Share to Bilirubin
Share to Chondroitin Sulfate Proteoglycans
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Share to Lipase
Share to Protein Phosphatase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28594920
DOI: 10.1371/journal.pone.0178685
PMCID: PMC5464588

Genes

GCKR
LYPLAL1
MBOAT7
NCAN
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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