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Article

Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.

Journal of nutrigenetics and nutrigenomics - 1 Jan 2011

Stover Patrick J

Abstract excerpt

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated...

Topics

Alleles
Animals
Carbon
Chromatin
DNA Methylation
DNA Modification Methylases
Epigenomics
Folic Acid
Genetic Variation
Homocysteine
Humans
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Nutritional Sciences

Polymorphism, Genetic

Vitamin B Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 22353665
DOI: 10.1159/000334586
PMCID: PMC3696357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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