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Article

Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development.

Molecular and cellular biology - 1 Feb 2016

Hagelkruys Astrid, Mattes Katharina, Moos Verena, Rennmayr Magdalena, Ringbauer Manuela, Sawicka Anna, Seiser Christian

Abstract excerpt

The class I histone deacetylases (HDACs) HDAC1 and HDAC2 play partially redundant roles in the regulation of gene expression and mouse development. As part of multisubunit corepressor complexes, these two deacetylases exhibit both enzymatic and nonenzymatic functions. To examine the impact of the catalytic activities of HDAC1 and HDAC2, we generated knock-in mice expressing catalytically inactive isoforms, which...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26598605
DOI: 10.1128/MCB.00639-15
PMCID: PMC4719423

Genes

HDAC2
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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