Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trans-regulation of histone deacetylase activities through acetylation.

The Journal of biological chemistry - 11 Dec 2009

Luo Yi, Jian Wei, Stavreva Diana, Fu Xueqi, Hager Gordon, Bungert Jörg, Huang Suming, Qiu Yi

Abstract excerpt

HDAC1 and -2 are highly conserved enzymes and often coexist in the same coregulator complexes. Understanding the regulation of histone deacetylase activities is extremely important because these enzymes play key roles in epigenetic regulation in normal and cancer cells. We previously showed that HDAC1 is required for glucocorticoid receptor-mediated transcription activation and that its activity is regulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Histone Deacetylase 1
Share to p300-CBP Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Glucocorticoid

Share to Recombinant Fusion Proteins

Share to RNA, Small Interfering

Share to Sequence Alignment

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 19822520
DOI: 10.1074/jbc.M109.038356
PMCID: PMC2787352

Genes

HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-regulation of histone deacetylase activities through acetylation.PMID 19822520Read ↗

The SIRT2 Deacetylase Regulates Autoacetylation of p300Semantic proximity Read ↗

Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesisSemantic proximity Read ↗

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared TasksSemantic proximity Read ↗

Regulatory signal transduction pathways for class IIa histone deacetylasesSemantic proximity Read ↗

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and AutoacetylationSemantic proximity Read ↗

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation BalanceSemantic proximity Read ↗

The Human Histone Deacetylase FamilySemantic proximity Read ↗

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological ActionabilitySemantic proximity Read ↗

Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.Semantic proximity Read ↗

Histone acetylation and deacetylation: importance in inflammatory lung diseasesSemantic proximity Read ↗

In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation.Semantic proximity Read ↗

Recent advances in class IIa histone deacetylases researchSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.