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Article

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Montgomery Rusty L, Hsieh Jenny, Barbosa Ana C, Richardson James A, Olson Eric N

Abstract excerpt

The molecular mechanism by which neural progenitor cells commit to a specified lineage of the central nervous system remains unknown. We show that HDAC1 and HDAC2 redundantly control neuronal development and are required for neuronal specification. Mice lacking HDAC1 or HDAC2 in neuronal precursors show no overt histoarchitectural phenotypes, whereas deletion of both HDAC1 and HDAC2 in developing neurons results...

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Source

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Identifiers

PMID: 19380719
DOI: 10.1073/pnas.0902750106
PMCID: PMC2683090

Genes

HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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