Article
CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study.
Drugs & aging - 1 Dec 2015
Opdam F L, Modak A S, Mooijaart S P, Louwerens M, de Waal M W M, Gelderblom H, Guchelaar H-J
Abstract excerpt
BACKGROUND: Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy subjects. METHODS: The (13)C-dextromethorphan breath test (DM-BT) was used to determine CYP2D6...
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