Article
Cytochrome P450 2D6 phenotyping in an elderly population with dementia and response to galantamine in dementia: a pilot study.
The American journal of geriatric pharmacotherapy - 1 Aug 2011
Clarke Jo-Anne, Cutler Murray, Gong Inna, Schwarz Ute I, Freeman David, Dasgupta Monidipa
Abstract excerpt
BACKGROUND: The cytochrome P450 (CYP) 2D6 enzyme is involved in the metabolism of many drugs used by the elderly population. Variations in its activity can lead to altered drug response. However, few studies on the activity of this enzyme system have enrolled the elderly population. OBJECTIVE: The goal of this pilot study was to assess the feasibility of in vivo phenotyping of CYP2D6 in an elderly population with...
Topics
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cholinesterase Inhibitors
- Cytochrome P-450 CYP2D6
- Dementia
- Female
- Galantamine
- Humans
- Male
- Middle Aged
- Phenotype
- Pilot Projects
- Treatment Outcome