Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2016

Chen Yan, Xu Qian, Ji Dexiang, Wei Yanlin, Chen Huamei, Li Tingting, Wan Bolin, Yuan Liya, Huang Ruibin, Chen Guoan

Abstract excerpt

Pentose phosphate pathway (PPP) is a metabolic pathway that generates NADPH and pentose. PPP genes have been reported to be primarily or secondarily upregulated in many cancers. We aimed to study the general alteration of PPP in acute myelogenous leukemia (AML). We performed data mining and analysis of the Cancer Genome Atlas (TCGA) AML dataset for genetic alteration of the PPP gene set. In vitro studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computational Biology

Share to Gene Expression Regulation, Leukemic

Share to Glucose

Share to Leukemia, Myeloid, Acute

Share to Oxidation-Reduction

Share to Pentose Phosphate Pathway

Source

Identifiers

PMID: 26596840
DOI: 10.1007/s13277-015-4428-5

Genes

PFKL
PFKP
PGLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia.PMID 26596840Read ↗

The Emerging Roles of the Metabolic Regulator G6PD in Human CancersSemantic proximity Read ↗

The HNRNPC/CELF2 signaling pathway drives glycolytic reprogramming and mitochondrial dysfunction in drug-resistant acute myeloid leukemiaSemantic proximity Read ↗

Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targetsSemantic proximity Read ↗

Glucose-6-phosphate Dehydrogenase: a Biomarker and Potential Therapeutic Target for CancerSemantic proximity Read ↗

PCNA regulates primary metabolism by scaffolding metabolic enzymes.Semantic proximity Read ↗

Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?Semantic proximity Read ↗

Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms.Semantic proximity Read ↗

Identification of glucuronic acid as a biomarker of poor prognosis in acute myeloid leukemia based on plasma metabolomicsSemantic proximity Read ↗

PGK1, a promising biomarker and therapeutic target for patients with acute myeloid leukemia who are susceptible to disease relapseSemantic proximity Read ↗

Targeting glutamine metabolism in myeloproliferative neoplasms.Semantic proximity Read ↗

Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative NeoplasmsSemantic proximity Read ↗

Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.