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The Emerging Roles of the Metabolic Regulator G6PD in Human Cancers

7 Dec 2023

Abstract excerpt

Metabolic reprogramming, especially reprogrammed glucose metabolism, is a well-known cancer hallmark related to various characteristics of tumor cells, including proliferation, survival, metastasis, and drug resistance. Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), a branch of glycolysis, that converts glucose-6-phosphate (G6P) into...

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PMID: 38139067
DOI: 10.3390/ijms242417238

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