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The HNRNPC/CELF2 signaling pathway drives glycolytic reprogramming and mitochondrial dysfunction in drug-resistant acute myeloid leukemia

16 May 2025

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive cancer with high treatment resistance, often leading to poor patient outcomes. Metabolic reprogramming plays a critical role in AML progression, influencing drug resistance (DR) and tumor survival. This study investigates the HNRNPC/CELF2 signaling pathway and its impact on AML cell metabolism and DR. RESULTS: The study identified that HNRNPC regulates the...

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PMID: 40380235
DOI: 10.1186/s13578-025-01386-x

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