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Article

Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?

European journal of haematology - 1 Mar 2016

Hauge Michelle, Bruserud Øystein, Hatfield Kimberley Joanne

Abstract excerpt

Targeting of cellular metabolism has emerged as a possible strategy in the treatment of human malignancies, and several experimental studies suggest that this therapeutic approach should also be considered in acute myeloid leukemia (AML). Clinical studies of metabolic intervention in AML patients with isocitrate dehydrogenase mutations have shown promising results. Moreover, metabolic targeting of the...

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PMID: 26465810
DOI: 10.1111/ejh.12690

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