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Article

PCNA regulates primary metabolism by scaffolding metabolic enzymes.

Oncogene - 1 Feb 2023

Røst Lisa M, Ræder Synnøve B, Olaisen Camilla, Søgaard Caroline K, Sharma Animesh, Bruheim Per, Otterlei Marit

Abstract excerpt

The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication and repair are well established, while its cytosolic roles are less explored. Two metabolic enzymes, alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), both contain PCNA interacting motifs. Mutation of the PCNA interacting motif APIM in ENO1 (F423A) impaired its binding to PCNA and resulted in...

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Identifiers

PMID: 36564470
DOI: 10.1038/s41388-022-02579-1
PMCID: PMC9937922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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