Targeting of heme oxygenase‐1 as a novel immune regulator of neuroblastoma

Abstract excerpt

Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the first time a prognostic relevance of HO-1 expression in samples from NB patients and show that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Heme Oxygenase-1 and Carbon Monoxide
• Share to Hemoglobin structure and function
• Share to Neonatal Health and Biochemistry