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Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis

3 Dec 2015

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial childhood tumor classified in five stages (1, 2, 3, 4 and 4S), two of which (3 and 4) identify chemotherapy-resistant, highly aggressive disease. High-risk NB frequently displays MYCN amplification, mutations in ALK and ATRX, and genomic rearrangements in TERT genes. These NB subtypes are also characterized by reduced susceptibility to programmed cell death...

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PMID: 26633716
DOI: 10.1038/cddis.2015.354

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