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Carbon Monoxide Mediates the Anti-apoptotic Effects of Heme Oxygenase-1 in Medulloblastoma DAOY Cells via K+ Channel Inhibition

17 May 2012

Abstract excerpt

Tumor cell survival and proliferation is attributable in part to suppression of apoptotic pathways, yet the mechanisms by which cancer cells resist apoptosis are not fully understood. Many cancer cells constitutively express heme oxygenase-1 (HO-1), which catabolizes heme to generate biliverdin, Fe 2+ , and carbon monoxide (CO). These breakdown products may play a role in the ability of cancer cells to suppress...

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PMID: 22593583
DOI: 10.1074/jbc.m112.357012

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