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Article

Notch1 Expression Predicts an Unfavorable Prognosis and Serves as a Therapeutic Target of Patients with Neuroblastoma

24 Aug 2010

Abstract excerpt

PURPOSE: Notch signaling has been implicated to play a critical role in the tumorigenesis of neuroblastoma (NB) and can modulate calreticulin (CRT) expression that strongly correlates with tumor differentiation and favorable prognosis of NB. We thus sought to determine how Notch regulates CRT expression and affects NB tumor behavior. EXPERIMENTAL DESIGN: The Notch-dependent regulation of CRT expression in...

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PMID: 20736329
DOI: 10.1158/1078-0432.ccr-09-3360

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