Article
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
Oncotarget - 5 Jan 2016
Santacatterina Fulvio, Sánchez-Cenizo Laura, Formentini Laura, Mobasher Maysa A, Casas Estela, Rueda Carlos B, Martínez-Reyes Inmaculada, Núñez de Arenas Cristina, García-Bermúdez Javier, Zapata Juan M, Sánchez-Aragó María, Satrústegui Jorgina, Valverde Ángela M, Cuezva José M
Abstract excerpt
The ATPase Inhibitory Factor 1 (IF1) is an inhibitor of the mitochondrial H+-ATP synthase that regulates the activity of both oxidative phosphorylation (OXPHOS) and cell death. Here, we have developed transgenic Tet-On and Tet-Off mice that express a mutant active form of hIF1 in the hepatocytes to restrain OXPHOS in the liver to investigate the relevance of mitochondrial activity in hepatocarcinogenesis. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.