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Article

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

Journal of medicinal chemistry - 10 Dec 2020

Xu Yibin, Xue Ding, Bankhead Armand, Neamati Nouri

Abstract excerpt

Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive. Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to chemotherapy and targeted therapies. Suppressing the OXPHOS function might also influence the tumor microenvironment by alleviating hypoxia and improving the antitumor immune response. Thus, targeting OXPHOS is a promising strategy...

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Identifiers

PMID: 33103432
DOI: 10.1021/acs.jmedchem.0c01013
PMCID: PMC9298160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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