Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

1 Apr 2019

Abstract excerpt

Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor, fails to kill human cancer cells in vitro. Driven by this consideration, we attempted to identify agents that engage in synthetically lethal interactions with B87. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30995479
DOI: 10.1016/j.celrep.2019.03.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-KetoglutaratePMID 30995479Read ↗

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.Semantic proximity Read ↗

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?Semantic proximity Read ↗

Metabolically inducing defects in DNA repair sensitizes BRCA –wild-type cancer cells to replication stressSemantic proximity Read ↗

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells.Semantic proximity Read ↗

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistanceSemantic proximity Read ↗

Functional linkage between mitochondrial electron transport, glycolysis, and AMP-activated protein kinase signaling underlying cancer cell survivalSemantic proximity Read ↗

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.Semantic proximity Read ↗

Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvationSemantic proximity Read ↗

Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma CellsSemantic proximity Read ↗

Succinate Dehydrogenase-Deficient Cancer Cells Have Increased Susceptibility to Ym155 Induced DNA DamageSemantic proximity Read ↗

A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugsSemantic proximity Read ↗

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.