Article
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo.
Oncotarget - 5 Jan 2016
Safavi Setareh, Järnum Sofia, Vannas Christoffer, Udhane Sameer, Jonasson Emma, Tomic Tajana Tesan, Grundevik Pernilla, Fagman Henrik, Hansson Magnus, Kalender Zeynep, Jauhiainen Alexandra, Dolatabadi Soheila, Stratford Eva Wessel, Myklebost Ola, Eriksson Mikael, Stenman Göran, Schneider-Stock Regine, Ståhlberg Anders, Åman Pierre
Abstract excerpt
Myxoid sarcoma (MLS) is one of the most common types of malignant soft tissue tumors. MLS is characterized by the FUS-DDIT3 or EWSR1-DDIT3 fusion oncogenes that encode abnormal transcription factors. The receptor tyrosine kinase (RTK) encoding RET was previously identified as a putative downstream target gene to FUS-DDIT3 and here we show that cultured MLS cells expressed phosphorylated RET together with its...
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