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Article

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.

BMC cancer - 25 Jan 2012

Haupt Armin, Joberty Gerard, Bantscheff Marcus, Fröhlich Holger, Stehr Henning, Schweiger Michal R, Fischer Axel, Kerick Martin, Boerno Stefan T, Dahl Andreas, Lappe Michael, Lehrach Hans, Gonzalez Cayetano, Drewes Gerard, Lange Bodo Mh

Abstract excerpt

BACKGROUND: The heat shock protein 90 (Hsp90) is required for the stability of many signalling kinases. As a target for cancer therapy it allows the simultaneous inhibition of several signalling pathways. However, its inhibition in healthy cells could also lead to severe side effects. This is the first comprehensive analysis of the response to Hsp90 inhibition at the kinome level. METHODS: We quantitatively...

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Identifiers

PMID: 22277058
DOI: 10.1186/1471-2407-12-38
PMCID: PMC3342885

Genes

RIPK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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