Article
A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas.
European journal of cancer (Oxford, England : 1990) - 1 May 2024
Lippai Zoltán, Péterfia Bálint, Papp Gergő, Dezső Katalin, Bedics Gábor, Pápai Zsuzsanna, Lamers Meindert H, Kuin Rosan Cm, Szuhai Károly, Sápi Zoltán
Abstract excerpt
INTRODUCTION: Dedifferentiated liposarcoma (DDLPS) is a common form of liposarcoma with challenging treatment modalities. Pan-TRK immunopositivity can be often observed without NTRK gene fusion in soft tissue sarcomas with myogenic differentiation. Expression and the role of NTRK in DDLPS are under-studied. We sought to identify activating mutations of the NTRK genes. MATERIALS AND METHODS: 131 DDLPS patients...
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