Article
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
Science signaling - 10 Mar 2020
Wu Pui-Kei, Hong Seung-Keun, Chen Wenjing, Becker Andrew E, Gundry Rebekah L, Lin Chien-Wei, Shao Hao, Gestwicki Jason E, Park Jong-In
Abstract excerpt
Mortalin [also known as heat shock protein family A (HSP70) member 9 (HSPA9) or glucose-regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often up-regulated and mislocalized in tumors with abnormal activation of the kinases MEK and ERK. Here, we found that mortalin depletion was selectively lethal to tumor and immortalized normal cells expressing the mutant kinase B-RafV600E or the...
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