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Article

Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas

1 Nov 2004

Abstract excerpt

Myxoid/round cell liposarcomas (MLS/RCLS) are characterized by chromosome translocations that result in formation of FUS-CHOP or EWSR1-CHOP fusion oncogenes. More than 95% of the tumors carry one of these fusion genes. FUS-CHOP transforms 3T3 cells and causes MLS/RCLS-like tumors in transgenic mice. The fusion oncoproteins act as abnormal transcription factors and are believed to induce abnormal expression of...

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PMID: 15492825
DOI: 10.3892/ijo.25.5.1349

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