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Article

The Expression of BAFF Is Controlled by IRF Transcription Factors

20 Nov 2015

Abstract excerpt

Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are typically characterized by the presence of autoantibodies and an IFN-signature. The strength of the IFN-signature positively correlates with disease severity, suggesting that type I IFNs are active players in these diseases. BAFF is a cytokine critical for development and proper selection of B cells, and the targeting of...

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PMID: 26590315
DOI: 10.4049/jimmunol.1501061

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