Implications of IFNγ SNP rs2069705 in primary Sjögren's syndrome: transcriptional activation and B cell infiltration.

doi:10.1152/ajpcell.00661.2023

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Article

Implications of IFNγ SNP rs2069705 in primary Sjögren's syndrome: transcriptional activation and B cell infiltration.

American journal of physiology. Cell physiology - 1 May 2024

Chen Xi, Li Min, Li Honglin, Liu Miao, Su Jianrong, Ji Yuzhu

Abstract excerpt

Primary Sjögren's syndrome (pSS) is characterized by its autoimmune nature. This study investigates the role of the IFNγ SNP rs2069705 in modulating the susceptibility to pSS. Differential expression of IFNγ and BAFF was analyzed using the GEO database's mRNA microarray GSE84844. Genotyping of the IFNγ SNP rs2069705 was conducted via the dbSNP website. The JASPAR tool was used for predicting transcription factor...

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Identifiers

PMID: 38406824
DOI: 10.1152/ajpcell.00661.2023
PMCID: PMC11371360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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