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Article

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage

20 Nov 2015

Abstract excerpt

IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental colitis and human inflammatory bowel disease. Germ-free mice failed to induce IL-36γ in response to dextran sodium sulfate (DSS)-induced damage, suggesting that gut microbiota are involved in its induction. Surprisingly, IL-36R-deficient (Il1rl2(-/-)) mice...

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PMID: 26590314
DOI: 10.4049/jimmunol.1501312

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