Article
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
Mucosal immunology - 1 Mar 2022
Leon Gemma, Hernandez Santana Yasmina E, Irwin Naoise, Giannoudaki Eirini, O'Neill Sadhbh, Csizmadia Ilona, Gogarty Martina, Lee Tae J, Ruane Darren, Long Aideen, Fallon Padraic G, Hussey Seamus, Walsh Patrick T
Abstract excerpt
IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate these effects remain to be fully uncovered. Here, we report specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, paediatric...
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