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Article

Molecular aspects of Interleukin-36 cytokine activation and regulation

28 Jun 2024

Abstract excerpt

Interleukin-36 (IL-36) cytokines are structurally similar to other Interleukin-1 superfamily members and are essential to convey inflammatory responses at epithelial barriers including the skin, lung, and gut. Due to their potent effects on immune cells, IL-36 cytokine activation is regulated on multiple levels, from expression and activation to receptor binding. Different IL-36 isoforms convey specific responses...

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PMID: 38940747
DOI: 10.1042/bst20230548

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