Article

Deficiency of IL-36 receptor antagonist (DITRA) is associated with decreased homoeostatic CCL27 expression leading to heightened dermal inflammation

2026-06-12

Abstract excerpt

Deficiency of the Interleukin-36 Receptor antagonist (DITRA) is a rare autoinflammatory condition which commonly manifests as severe, recurrent episodes of Generalized Pustular Psoriasis (GPP). Loss-of-function mutations in the IL36RN gene result in unopposed IL-36 cytokine signalling leading to severe psoriatic inflammation, which can be successfully treated with Anti-IL-36 receptor (IL-36R) monoclonal antibodie...

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Literature Corpus work: ef5fcfd1-27f9-5beb-9673-c68d90cd14d8
DOI: 10.64898/2026.06.11.731561

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