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IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore

7 Aug 2021

Abstract excerpt

The IL-36 family of cytokines were first identified in 2000 based on their sequence homology to IL-1 cytokines. Over subsequent years, the ability of these cytokines to either agonise or antagonise an IL-1R homologue, now known as the IL-36 Receptor (IL-36R), was identified and these cytokines went through several cycles of renaming with the current nomenclature being proposed in 2010. Despite being identified...

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PMID: 34365521
DOI: 10.1007/s00018-021-03909-4

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