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The complex roles of IL-36 and IL-38 in cancer: friends or foes?

7 Mar 2025

Abstract excerpt

The interleukin-36 (IL-36) family comprises of three pro-inflammatory receptor agonists (IL-36α, IL-36β and IL-36γ), two anti-inflammatory receptor antagonists (IL-36RA and IL-38) along with the IL-36 receptor (IL-36R). Part of the IL-1 cytokine superfamily, the IL-36 family was discovered in the early 2000s due to the homology of its member sequences to the IL-1 cytokines. As pro- and anti-inflammatory...

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PMID: 40057603
DOI: 10.1038/s41388-025-03293-4

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