Article
Genome-wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia.
British journal of haematology - 1 Nov 2024
Zhu Qianqian, Nambiar Ram, Schultz Emily, Gao Xinyu, Liang Shuyi, Flamand Yael, Stevenson Kristen, Cole Peter D, Gennarini Lisa, Harris Marian H, Kahn Justine M, Ladas Elena J, Athale Uma H, Hoa Tran Thai, Michon Bruno, Welch Jennifer J G, Sallan Stephen E, Silverman Lewis B, Kelly Kara M, Yao Song
Abstract excerpt
Bone toxicities are common among paediatric patients treated for acute lymphoblastic leukaemia (ALL) with potentially major negative impact on patients' quality of life. To identify the underlying genetic contributors, we conducted a genome-wide association study (GWAS) and a transcriptome-wide association study (TWAS) in 260 patients of European-descent from the DFCI 05-001 ALL trial, with validation in 101...
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