Article
Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients.
Leukemia - 1 Feb 2015
Wesołowska-Andersen A, Borst L, Dalgaard M D, Yadav R, Rasmussen K K, Wehner P S, Rasmussen M, Ørntoft T F, Nordentoft I, Koehler R, Bartram C R, Schrappe M, Sicheritz-Ponten T, Gautier L, Marquart H, Madsen H O, Brunak S, Stanulla M, Gupta R, Schmiegelow K
Abstract excerpt
Childhood acute lymphoblastic leukemia survival approaches 90%. New strategies are needed to identify the 10-15% who evade cure. We applied targeted, sequencing-based genotyping of 25 000 to 34 000 preselected potentially clinically relevant single-nucleotide polymorphisms (SNPs) to identify host genome profiles associated with relapse risk in 352 patients from the Nordic ALL92/2000 protocols and 426 patients...
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