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Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia.

Molecular diagnosis & therapy - 1 Dec 2016

den Hoed Marissa A H, Pluijm Saskia M F, Uitterlinden André G, Pieters Rob, van den Heuvel-Eibrink Marry M

Abstract excerpt

Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been identified as being associated with osteonecrosis; however, a prediction model that combines pretreatment genetic biomarkers and clinical factors has not yet been...

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PMID: 27365083
DOI: 10.1007/s40291-016-0226-z

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