Article
Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 is Associated with an Increased HLA-C2 Allelic Frequency.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Feb 2016
Dambaeva Svetlana V, Lee Dong Hyung, Sung Nayoung, Chen Chi-Yao, Bao Shihua, Gilman-Sachs Alice, Kwak-Kim Joanne, Beaman Kenneth D
Abstract excerpt
PROBLEM: During human pregnancy, the uterine lining is highly populated with killer-immunoglobulin-like receptor (KIR)-expressing NK cells that recognize HLA-C molecules on trophoblast cells. The goal of this study was to analyze the KIR gene contents and frequencies in a N. American cohort of women with RPL of unknown etiology to evaluate whether there is a genetic susceptibility to RPL based on a woman's KIR...
Topics
- Abortion, Habitual
- Adult
- Female
- Gene Frequency
- Genotype
- HLA-C Antigens
- Humans
- North America
- Pregnancy
- Receptors, KIR
- White People