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Article

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.

Hepatology (Baltimore, Md.) - 1 Dec 2016

Prentoe Jannick, Velázquez-Moctezuma Rodrigo, Foung Steven K H, Law Mansun, Bukh Jens

Abstract excerpt

There are 3-4 million new hepatitis C virus (HCV) infections yearly. The extensive intergenotypic sequence diversity of envelope proteins E1 and E2 of HCV and shielding of important epitopes by hypervariable region 1 (HVR1) of E2 are believed to be major hindrances to developing universally protective HCV vaccines. Using cultured viruses expressing the E1/E2 complex of isolates H77 (genotype 1a), J6 (2a), or S52...

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Identifiers

PMID: 27351277
DOI: 10.1002/hep.28705
PMCID: PMC5115964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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