Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice.

Journal of hepatology - 1 May 2022

Pihl Anne Finne, Feng Shan, Offersgaard Anna, Alzua Garazi Peña, Augestad Elias Honerød, Mathiesen Christian Kjaerulff, Jensen Tanja Bertelsen, Krarup Henrik, Law Mansun, Prentoe Jannick, Christensen Jan Pravsgaard, Bukh Jens, Gottwein Judith Margarete

Abstract excerpt

BACKGROUND & AIMS: A prophylactic vaccine is required to eliminate HCV as a global public health threat. We developed whole virus inactivated HCV vaccine candidates employing a licensed adjuvant. Further, we investigated the effects of HCV envelope protein modifications (to increase neutralization epitope exposure) on immunogenicity. METHODS: Whole virus vaccine antigen was produced in Huh7.5 hepatoma cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antigens, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to Hepatitis C

Share to Hepatitis C Antibodies

Share to Mice, Inbred BALB C

Share to Viral Envelope Proteins

Share to Viral Hepatitis Vaccines

Source

Identifiers

PMID: 34990750
DOI: 10.1016/j.jhep.2021.12.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice.PMID 34990750Read ↗

Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice.Semantic proximity Read ↗

From Structural Studies to HCV Vaccine Design.Semantic proximity Read ↗

Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance.Semantic proximity Read ↗

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes.Semantic proximity Read ↗

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.Semantic proximity Read ↗

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in HumansSemantic proximity Read ↗

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.Semantic proximity Read ↗

A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice.Semantic proximity Read ↗

A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization ResistanceSemantic proximity Read ↗

Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization.Semantic proximity Read ↗

Viral evasion and challenges of hepatitis C virus vaccine development.Semantic proximity Read ↗

Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.