Article

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model

2020-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Infection with hepatitis C virus (HCV) remains to be a major cause of morbidity and mortality worldwide despite the recent advent of highly effective direct-acting antivirals. The envelope glycoproteins of HCV are heavily glycosylated with a high proportion of high-mannose glycans (HMGs), which serve as a shield against neutralizing antibodies and assist in the interaction with cell-entry recept...

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Literature Corpus work: dcef6392-e832-5416-89c6-c6865a85dee2
DOI: 10.1101/2020.04.22.056754

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