Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.

doi:10.1186/s12985-020-01408-9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.

Virology journal - 18 Sept 2020

Mosa Alexander I, AbouHaidar Mounir G, Urbanowicz Richard A, Tavis John E, Ball Jonathan K, Feld Jordan J

Abstract excerpt

Despite available treatments, a prophylactic HCV vaccine is needed to achieve elimination targets. HCV vaccine development has faltered largely because the extreme diversity of the virus limits the protective breadth of vaccine elicited antibodies. It is believed that the principle neutralizing epitope in natural infection, HVR1, which is the most variable epitope in HCV, mediates humoral immune escape. So far,...

Topics

Animals
Antibodies, Neutralizing
Antibodies, Viral
Cross Reactions
Epitopes, B-Lymphocyte
Female
Genotype
Hepacivirus
Hepatitis C
Hepatitis C Antibodies
Humans
Mice
Mice, Inbred BALB C
Neutralization Tests
Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32948191
DOI: 10.1186/s12985-020-01408-9
PMCID: PMC7499410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics