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Article

Loss of function mutations of BCOR in classical Hodgkin lymphoma.

Leukemia & lymphoma - 1 May 2022

Giefing Maciej, Gearhart Micah D, Schneider Markus, Overbeck Birte, Klapper Wolfram, Hartmann Sylvia, Ustaszewski Adam, Weniger Marc A, Wiehle Laura, Hansmann Martin-Leo, Melnick Ari, Béguelin Wendy, Sundström Christer, Küppers Ralf, Bardwell Vivian J, Siebert Reiner

Abstract excerpt

BCOR is a component of a variant Polycomb repressive complex 1 (PRC1.1). PRC1 and PRC2 complexes together constitute a major gene regulatory system critical for appropriate cellular differentiation. The gene is upregulated in germinal center (GC) B cells and mutated in a number of hematologic malignancies. We report BCOR inactivating alterations in 4/7 classic Hodgkin lymphoma (cHL) cell lines, subclonal somatic...

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Identifiers

PMID: 34957890
DOI: 10.1080/10428194.2021.2015587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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