Article
Stromal cell-derived factor-1 rs2297630 polymorphism associated with platelet production and treatment response in Chinese patients with chronic immune thrombocytopenia.
Platelets - 1 Jun 2016
Lyu Mingen, Li Yang, Hao Yating, Sun Tiantian, Liu Wenjie, Lyu Cuicui, Fu Rongfeng, Li Huiyuan, Xue Feng, Liu Xiaofan, Zhang Lei, Yang Renchi
Abstract excerpt
Stromal cell-derived factor-1 (SDF-1), signaling through CXCR4, is implicated in megakaryopoiesis and platelet production. SDF-1 rs2297630 is a functional polymorphism in linkage disequilibrium with other functional variants in SDF-1. This study aimed to investigate the role of SDF-1 rs2297630 in chronic ITP. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and...
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