The role of gene polymorphisms in the susceptibility and therapeutic response of chronic immune thrombocytopenic purpura.

doi:10.1080/17474086.2026.2636163

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Article

The role of gene polymorphisms in the susceptibility and therapeutic response of chronic immune thrombocytopenic purpura.

Expert review of hematology - 1 May 2026

Moghaddasnejad Mohammad Reza, Aghaei Mojtaba, Saki Najmaldin

Abstract excerpt

INTRODUCTION: Chronic immune thrombocytopenic purpura (cITP) is a prolonged autoimmune disorder characterized by persistent low platelet counts and the presence of anti-platelet antibodies. The disease exhibits heterogeneity in severity and therapeutic response, which complicates management and underscores the importance of identifying predictive biomarkers. AREAS COVERED: This review examines gene polymorphisms...

Topics

Humans
Purpura, Thrombocytopenic, Idiopathic
Genetic Predisposition to Disease
Polymorphism, Genetic
Chronic Disease
Cytokines
Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 41948789
DOI: 10.1080/17474086.2026.2636163

Genes

ABCB1
CXCL12
ICOS
IL10
IL6
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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