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Article

Immune Checkpoint-Related Gene Polymorphisms Are Associated With Primary Immune Thrombocytopenia.

Frontiers in immunology - 1 Jan 2020

Wang Shuwen, Zhang Xiaoyu, Leng Shaoqiu, Xu Qirui, Sheng Zi, Zhang Yanqi, Yu Jie, Feng Qi, Hou Ming, Peng Jun, Hu Xiang

Abstract excerpt

Cancer immunotherapy by immune checkpoint blockade has been effective in the treatment of certain tumors. However, the association between immune checkpoints and autoimmune diseases remains elusive and requires urgent investigation. Primary immune thrombocytopenia (ITP), characterized by reduced platelet count and a consequent increased risk of bleeding, is an autoimmune disorder with a hyper-activated T cell...

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Identifiers

PMID: 33584705
DOI: 10.3389/fimmu.2020.615941
PMCID: PMC7874092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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