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Article

The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP.

BMC immunology - 16 May 2017

Takahashi Noriyuki, Saitoh Takayuki, Gotoh Nanami, Nitta Yasuhiro, Alkebsi Lobna, Kasamatsu Tetsuhiro, Minato Yusuke, Yokohama Akihiko, Tsukamoto Norifumi, Handa Hiroshi, Murakami Hirokazu

Abstract excerpt

BACKGROUND: T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional polymorphisms on both susceptibility to, and severity of, cITP. We analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, and IL-4Rα Q576R polymorphisms in 126 cITP patients (male/female: 34/92;...

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Identifiers

PMID: 28511637
DOI: 10.1186/s12865-017-0210-3
PMCID: PMC5434613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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