Article
Interleukin-10 gene polymorphism reflects the severity of chronic immune thrombocytopenia in Japanese patients.
International journal of laboratory hematology - 1 Oct 2011
Saitoh T, Kasamatsu T, Inoue M, Mitsui T, Koiso H, Yokohama A, Handa H, Matsushima T, Tsukamoto N, Karasawa M, Ogawara H, Nojima Y, Murakami H
Abstract excerpt
INTRODUCTION: T-helper cell type 1 (Th1) polarization of the immune response has been documented in patients with chronic immune thrombocytopenia (ITP). Interleukin (IL)-10 is the most important factor regulating Th1 and T-helper type 2 cytokine synthesis. This study evaluated the impact of IL-10 polymorphisms on both susceptibility to, and severity of, chronic ITP. METHODS: We analyzed -1082(G/A), -812(C/T), and...
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