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Article

A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Hayashi Hideki, Tazoe Yui, Tsuboi Seiji, Horino Masato, Morishita Mariko, Arai Teruhisa, Ohshima Motohiro, Matsuyama Taiji, Kosuge Kazuhiro, Yamada Hiroshi, Tsuji Daiki, Inoue Kazuyuki, Itoh Kunihiko

Abstract excerpt

Methotrexate (MTX) exhibits large inter-individual and inter-ethnic differences in the dose required for its anti-rheumatic effect. To maintain low disease activity, patients may require increased MTX doses or co-administration of biologic disease-modifying anti-rheumatic drugs (bDMARDs). The availability of a marker predicting the effect of MTX will make it possible to increase the MTX dose and prescribe bDMARDs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22971639
DOI: 10.2133/dmpk.dmpk-12-nt-038

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis.PMID 22971639Read ↗

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Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.Semantic proximity Read ↗

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