Article
Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians.
Pharmacogenetics and genomics - 1 Dec 2008
Sharma Shruti, Das Mitashree, Kumar Ashok, Marwaha Vishal, Shankar Subramanian, Aneja Ritu, Grover Rahul, Arya Vivek, Dhir Varun, Gupta Rajiva, Kumar Uma, Juyal Ramesh C, B K Thelma
Abstract excerpt
OBJECTIVE: Methotrexate (MTX) is the drug of choice for rheumatoid arthritis (RA) but is effective only in around 60% of treated patients. Bioavailability of MTX may be a major determinant of response status and this may be governed by variations in MTX receptor and transporter genes and genes responsible for polyglutamation and deconjugation. We investigated the contribution of single nucleotide polymorphisms...
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